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MUC1 (phospho Y1229), Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Catalog No. 89130723 Shop All Abnova Corporation Products
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89-130-723 100 μL
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Catalog No. 89-130-723 Supplier Abnova Corporation Supplier No. PAB29286
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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MUC1.

This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. [provided by RefSeq

Specifications

Antigen MUC1
Applications Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MUC1.
Dilution Immunofluorescence (1:100∼1:200) Immunohistochemistry (1:50∼1:100) Western Blot (1:500∼1:1000) The optimal working dilution should be determined by the end user.
Formulation In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene MUC1
Gene Alias CD227/EMA/H23AG/MAM6/PEM/PEMT/PUM
Gene Symbols MUC1
Host Species Rabbit
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1229 of human MUC1.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4582
Test Specificity MUC1 (phospho Y1229) polyclonal antibody detects endogenous levels of human MUC1 only when phosphorylated at tyrosine 1229.
Target Species Human, Mouse
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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