NFKBIA (phospho Y42), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic phosphopeptide of NFKBIA.
Manufacturer: Abnova Corporation PAB25388
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIMSequence: E-E-Yp-E-Q
|Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.|
|Immunohistochemistry (PFA fixed)|
|Rabbit polyclonal antibody raised against synthetic phosphopeptide of NFKBIA.|
|In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|Synthetic phosphopeptide corresponding to residues surrounding Y42 of human NFKBIA.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Human, Murine, Rat|
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