NOTCH1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-114-762	200 μL

Catalog No. 89-114-762 Supplier Abnova Corporation Supplier No. PAB10291

Description

Rabbit polyclonal antibody raised against synthetic peptide of NOTCH1.

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq

Specifications

• Antigen: NOTCH1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of NOTCH1.
• Dilution: Sandwich ELISA (1:20000-1:60000) Western Blot (1:500) The optimal working dilution should be determined by the end user.
• Formulation: In 20mM KH₂PO₄, 150mM NaCl, pH 7.2 (0.1% sodium azide)
• Gene: NOTCH1
• Gene Alias: TAN1/hN1
• Gene Symbols: NOTCH1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to N-terminus the cleaved N intracellular domain (NICD) of human NOTCH1.
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4851
• Test Specificity: This antiserum is directed against human NOTCH 1. Only the cleaved intracellular (activated) form (NICD) is detected. No reactivity is detected against mouse N2, N3 or N4. The immunogen epitope is only exposed after gamma secretase cleavage and is not accessible in the uncleaved form.
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only