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NOTCH1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89121339 Shop All Abnova Corporation Products
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100 μg
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89-121-339 100 μg
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Catalog No. 89-121-339 Supplier Abnova Corporation Supplier No. PAB19809
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Description

Rabbit polyclonal antibody raised against synthetic peptide of NOTCH1.

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq

Specifications

Antigen NOTCH1
Applications ELISA, Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of NOTCH1.
Dilution ELISA (1:1000-1:10000) Immunohistochemistry (1:50-500) The optimal working dilution should be determined by the end user.
Formulation In serum (1% BSA, 0.02% sodium azide)
Gene NOTCH1
Gene Alias TAN1/hN1
Gene Symbols NOTCH1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to N-terminus of human NOTCH1.
Purification Method Peptide affinity purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4851
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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