NPC1 Rabbit anti-Hamster, Human, Mouse, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-115-592	100 μL

Catalog No. 89-115-592 Supplier Abnova Corporation Supplier No. PAB12093

Description

Rabbit polyclonal antibody raised against synthetic peptide of NPC1.

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments

Specifications

• Antigen: NPC1
• Applications: Immunofluorescence, Immunohistochemistry, Immunomicroscopy, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of NPC1.
• Dilution: Immunofluorescence (1:250) Western Blot (1:1000-1:3000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: NPC1
• Gene Alias: NPC
• Gene Symbols: NPC1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to amino acids 1230-1278 at C-terminus of human NPC1.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4864
• Test Specificity: This antibody is specific to NPC1 protein.
• Target Species: Hamster, Human, Mouse
• Content And Storage: Store at 4°C for short term. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only