NPC1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-118-587	100 μg

Catalog No. 89-118-587 Supplier Abnova Corporation Supplier No. PAB16750

Description

Rabbit polyclonal antibody raised against synthetic peptide of NPC1.

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments

Specifications

• Antigen: NPC1
• Applications: ELISA, Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of NPC1.
• Dilution: Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.02% sodium azide)
• Gene: NPC1
• Gene Alias: NPC
• Gene Symbols: NPC1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to C-terminus 16 amino acids of human NPC1.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4864
• Target Species: Human
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only