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Description
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq]
Specifications
Specifications
| Antigen | NPPB |
| Applications | ELISA, Immunohistochemistry, Radioimmune Assays (RIA) |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of NPPB. |
| Dilution | Immunofluorescence (1:1000) The optimal working dilution should be determined by the end user. |
| Formulation | Lyophilized from PBS, pH 7.2 |
| Gene | NPPB |
| Gene Alias | BNP |
| Gene Symbols | NPPB |
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