NR0B2, Rabbit, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of NR0B2.
Supplier: Abnova Corporation PAB27775
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic peptide of NR0B2.|
|In PBS (0.09% sodium azide)|
|Hamster, Human, Monkey, Mouse, Rabbit|
|Immunohistochemistry (PFA fixed)|
|Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4 ug/mL) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to 16 amino acid at ligand-binding domain of human NR0B2.|
|BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
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For Research Use Only