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NR0B2, Rabbit, Polyclonal Antibody, Abnova™

Catalog No. 89129294 Shop All Abnova Corporation Products
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89-129-294 50 μg
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Catalog No. 89-129-294 Supplier Abnova Corporation Supplier No. PAB27775
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Description

Rabbit polyclonal antibody raised against synthetic peptide of NR0B2.

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq

Specifications

Antigen NR0B2
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of NR0B2.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene NR0B2
Gene Alias FLJ17090/SHP/SHP1
Gene Symbols NR0B2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 16 amino acid at ligand-binding domain of human NR0B2.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8431
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Target Species Hamster, Human, Monkey, Mouse, Rabbit
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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