MilliporeSigma™ Rabbit anti-NRF-1, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABE1844

Catalog No. ABE1844MI

Description

Specifically detects NRF-1 in Human, Mouse, Rat samples, and it is validated for Chromatin Immunoprecipitation, Immunocytochemistry, Western Blotting

Nuclear respiratory factor (UniProt Q9WU00; also known as Alpha-pal, Alpha palindromic-binding protein, NRF-1) is encoded by the Nrf1 gene (also known as C87038, D6Ertd415e) in murine species (Gene ID 18181). NRF-1 is a redox-responsive transcription factor that plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process. NRF-1 is upregulated and activated/phosphorylated by Akt in response to oxidant exposure or increased cellular reactive oxygen species (ROS). This results in NRF-1 nuclear translocation, where it binds to DNA as a homodimer and mediates the transcription of mitochondrial transcription factor A (mtTFA) that is needed for mitochondrial DNA transcription.

Specifications

• Antigen: NRF-1
• Classification: Polyclonal
• Gene Accession No.: Q9WU00
• Host Species: Rabbit
• Purification Method: Protein A Purfied
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Purified

• Applications: ChIP Assay, Immunocytochemistry, Western Blot
• Formulation: Purified rabbit polyclonal antibody in buffer containing PBS and 0.01% Sodium Azide.
• Gene Symbols: Nrf1
• Immunogen: KLH-conjugated linear peptide corresponding to mouse NRF-1.
• Quantity: 200 μg
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_001157698
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only