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NUDT1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89115589 Shop All Abnova Corporation Products
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200 μL
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89-115-589 200 μL
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Catalog No. 89-115-589 Supplier Abnova Corporation Supplier No. PAB12088
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Description

Rabbit polyclonal antibody raised against synthetic peptide of NUDT1.

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq

Specifications

Antigen NUDT1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of NUDT1.
Dilution Immunocytochemistry (1:50-1:200) Immunofluorescence (1:50-1:200) Immunohistochemistry (Frozen sections) (1:200) Western Blot (1:500) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.05% sodium azide)
Gene NUDT1
Gene Alias MTH1
Gene Symbols NUDT1
Host Species Rabbit
Immunogen A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human NUDT1.
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4521
Test Specificity This antibody is specific to MTH1.
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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