MilliporeSigma™ Rabbit anti-Pancreatic Lipase/PNLIP, Polyclonal,

Catalog No.	Quantity
ABS547MI	100 μL

Catalog No. ABS547MI Supplier MilliporeSigma™ Supplier No. ABS547

Description

Rabbit Polyclonal Antibody

Specifically detects Pancreatic Lipase/PNLIP in Human, Mouse, Rat samples, and it is validated for Western Blotting

Pancreatic triacylglycerol lipase (EC 3.1.1.3; UniProt P35638; also known as Pancreatic lipase, PL, PTL, Triacylglycerol acylhydrolase) is encoded by the PNLIP (Also known as PNLIPD) gene in human (Gene ID 5406). PTL is a pancreas synthesized carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides (TAGs). The dietary TAGs are partially digested by the gastric lipase in the stomach. The emulsion particles then mix with digestive enzymes from the pancreas in the duodenum where digestion proceeds. The pancreas secretes multiple lipases, including pancreatic triglyceride lipase (PTL), carboxyl ester lipase (CEL), and pancreatic lipase-related protein-1 and -2 (PLRP1 & PLRP2). Unlike PLRP2, PLRP1 exhibits little activity against triglycerides and no measurable activity against phospholipids, galactolipids or cholesterol esters. Experimental evidences suggest that PLRP1 plays a negative regulatory role against PLT–colipase-mediated dietary triglyceride digestion. Pancreas-derived lipases are essential for the efficient digestion of dietary TAG. Pancreatic insufficiency or exocrine pancreas failure results in steatorrhea or steatorrhoea, where increased fat excretion is seen in fecal samples.

Specifications

• Antigen: Pancreatic Lipase/PNLIP
• Applications: Western Blot
• Classification: Polyclonal
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Accession No.: P16233
• Gene Symbols: PNLIP
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to human Pancreatic Lipase/PNLIP.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_000927
• Target Species: Human, Mouse, Rat
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Form: Serum

For Research Use Only