MilliporeSigma™ Rabbit anti-PAR-4, Polyclonal,

Catalog No.	Quantity
ABC502MI	100 μg

Catalog No. ABC502MI Supplier MilliporeSigma™ Supplier No. ABC502

Description

Rabbit Polyclonal Antibody

Specifically detects PAR-4 in Human samples, and it is validated for Western Blotting

PAR-4 is a pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells and sensitizing the cells to diverse apoptotic stimuli causing tumor regression. PAR-4 also seems to be a transcriptional repressor and is involved in regulating APP expression and the cleavage activity of BACE1. PAR-4 interacts with several proteins including WT1, but also various kinases, and structural proteins like Actin, BACE1, SPSB1, SPSB2, and SPSB4. PAR4 is localized in the cytoplasm in non-apoptotic cells but is nuclear localized in cancer and apoptotic cells. PAR-4 is widely expressed and elevated in neurodegenerative diseases such as ALS, Alzheimer, Parkinson and Huntington diseases as well as stroke. PAR-4 is down regulated in cancers.

Specifications

• Antigen: PAR-4
• Applications: Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q96IZ0
• Gene Symbols: PAWR; PAR4
• Host Species: Rabbit
• Immunogen: GST-tagged recombinant protein corresponding to the C-terminus of human PAR-4.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Apoptosis, Cancer
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_002574
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only