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Description
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined. [provided by RefSeq
Specifications
Specifications
| Antigen | PGR |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Monoclonal |
| Clone | SP42 |
| Conjugate | Unconjugated |
| Description | Rabbit monoclonal antibody raised against synthetic peptide of PGR. |
| Dilution | Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:400) The optimal working dilution should be determined by the end user. |
| Formulation | Tissue culture supernatant in TBS buffer, pH 7.5 (1% BSA, 0.09% sodium azide). |
| Gene | PGR |
| Gene Alias | NR3C3/PR |
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