MilliporeSigma™ Rabbit anti-phospho-AS160 (Thr642), Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABS271

Catalog No. ABS271MI

Description

Specifically detects phospho-AS160 (Thr642) in Human, Mouse samples, and it is validated for Western Blotting

AS160 is a widely expressed RAB-GTPase activating protein which plays a role in insulin action. AS160 is phosphorylated by AKT, AMPK, RSK, and SGK1. Upon phosphorylation, AS160 changes its location from microsomes to the cytosol upon insulin treatment. AS160 acts as key link between insulin signaling and GLUT4 trafficking of glucose. Phosphorylation of AS160 is essential for AS160 action and AS160 has multiple phosphorylation sites. Phosphorylation of AS160 on both AS160Thr642 and AS160Ser588 is important for insulin-stimulated glucose transport. Phosphorylation of these sites is predicted to inhibit AS160's activation of Rab-GTPase proteins and favor greater exocytosis of GLUT4 vesicles, leading ultimately to greater glucose transport. Research indicates that impairment of phosphorylation of AS160 at Thr642 is associated with various aspects of type 2 diabetes.

Specifications

• Antigen: phospho-AS160 (Thr642)
• Classification: Polyclonal
• Gene Accession No.: O60343
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse

• Applications: Western Blot
• Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: TBC1D4; AS160; KIAA0603
• Immunogen: KLH-conjugated linear peptide corresponding to human phospho-AS160 (Thr642).
• Quantity: 200 μL
• Research Discipline: Signaling
• Gene ID (Entrez): NP_055647
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only