MilliporeSigma Rabbit anti-phospho-CREB (Ser133), Alexa Fluor 488, Polyclonal,
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma 06519AF488
Specifically detects phospho-CREB (Ser133) in Human, Mouse, Rat samples, and it is validated for ImmunofluorescenceCyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes. CREB activity is regulation via phosphorylation by various kinases, including PKA, and Ca2+/calmodulin-dependent protein kinases. Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2. CREB is critical for memory formation across a wide range of species.
|Alexa Fluor 488|
|KLH-conjugated synthetic peptide corresponding to the amino acids including and encompassing phosphorylated Ser133 of CREB-A.|
|Stable for one year at 2°C to 8°C from date of receipt.|
|Human, Murine, Rat|
|Purified rabbit polyclonal antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.|
|Epigenetics and Nuclear Function|
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