MilliporeSigma™ Rabbit anti-phospho- NFkB p52, (Ser222), Polyclonal,

Catalog No.	Quantity
ABS1515MI	100 μL

Catalog No. ABS1515MI Supplier MilliporeSigma™ Supplier No. ABS1515

Description

Rabbit Polyclonal Antibody

Specifically detects phospho- NFkB p52, (Ser222) in Human samples, and it is validated for Western Blotting

The p52 NF-kB subunit is induced through activation of the alternative (noncanonical) NF-kB pathway in response to a range of stimuli such as lymphotoxin-b, BAFF and CD40, as well as DNA damage. The p52 formation results from proteolytic processing of its precursor protein p100 as a consequence of IKKalpha-mediated phosphorylation. The p52 is most commonly found as a heterodimer with RelB, although other dimer combinations have been identified by ChIP analysis. Ser222 of NF-kappa B p52 is phosphorylated by the kinase GSK3beta. Phosphorylation at S222 appears to regulate not only p52 partner dimerization but also the p52 dependent activation or repression of Skp2 gene expression.

Specifications

• Antigen: phospho- NFkB p52, (Ser222)
• Applications: Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q00653
• Gene Symbols: NFKB2; LYT10
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to the RHD domain of human phospho NFkB p52, (Ser222).
• Purification Method: Affinity Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_002493
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only