MilliporeSigma™ Rabbit anti-phospho-TrkA (Tyr794), Polyclonal,

Catalog No.	Quantity
ABN1383MI	100 μg

Catalog No. ABN1383MI Supplier MilliporeSigma™ Supplier No. ABN1383

Description

Rabbit Polyclonal Antibody

Specifically detects phospho-TrkA (Tyr794) in Human, Rat samples, and it is validated for Immunocytochemistry, Western Blotting

High affinity nerve growth factor receptor (EC 2.7.10.1; UniProt P35739; also known as Neurotrophic tyrosine kinase receptor type 1, p140-TrkA, Slow nerve growth factor receptor, Trk-A, TrkA neurotrophin receptor, TrkA proto-oncogene receptor, Tropomyosin-related kinase A) is encoded by the Ntrk1 gene (also known as Trk, Trka) in rat (Gene ID 59109). Neurotrophins mediate a wide range of neuronal functions, including survival, differentiation, growth, and death, via two classes of transmembrane receptors, the Trk receptor tyrosine kinase and the p75 neurotrophin receptor. While nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and NT-4 all bind the p75 receptor, TrkA is selective for NGF, TrkB is selective for BDNF and NT-4, and TrkC is selective for NT-3. TrkA and TrkB receptors can also be activated by ligands of the G-protein-coupled receptor (GPCRs), including the nucleoside adenosine or adenosine agonists, such as CGS 21680 and the pituitary adenylate cyclase-activating polypeptide (PACAP). In addition to transactivation via GPCRs, Glucocorticoids (GCs) are also reported to promote TrkA/B/C activation due to signaling cross-talk between Trk and GC receptor (GR).

Specifications

• Antigen: phospho-TrkA (Tyr794)
• Applications: Immunocytochemistry, Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P35739
• Gene Symbols: Ntrk1; Trk; Trka
• Host Species: Rabbit
• Immunogen: Linear peptide corresponding to rat TrkA sequence near the C-terminus with phosphorylated Tyr794.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Neuroscience
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_067600
• Target Species: Human, Rat
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only