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PLAU Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89116769 Shop All Abnova Corporation Products
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89-116-769 100 μg
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Catalog No. 89-116-769 Supplier Abnova Corporation Supplier No. PAB13618
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Description

Rabbit polyclonal antibody raised against recombinant PLAU.

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Specifications

Antigen PLAU
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against recombinant PLAU.
Dilution The optimal working dilution should be determined by the end user.
Formulation In 50mM sodium phosphate buffer, 150mM NaCl, pH 7.4
Gene PLAU
Gene Alias ATF/UPA/URK/UROKINASE/u-PA
Gene Symbols PLAU
Host Species Rabbit
Immunogen Recombinant protein corresponding to human PLAU.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5328
Test Specificity This polyclonal antibody is specific to human uPA (urokinase) and is useful for fibrnolytic and cancer studies. It is provided in the following manner for added convenience: Serum, IgG Fraction, Affinity Purified as well as labeled with Biotin or FITC. This antibody reacts with both free and complexed forms of uPA.
Target Species Human
Content And Storage Store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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