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PLAU Rabbit anti-Human, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of PLAU.
Supplier: Abnova Corporation PAB25150
Description
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Specifications
PLAU | |
Polyclonal | |
Unconjugated | |
Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user. | |
PLAU | |
PLAU | |
A synthetic peptide corresponding to PLAU. | |
100 μL | |
Primary | |
PLAU polyclonal antibody detects endogenous levels of PLAU protein. | |
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
Immunohistochemistry (PFA fixed) | |
1 mg/mL | |
Rabbit polyclonal antibody raised against synthetic peptide of PLAU. | |
In PBS, pH 7.2 (0.05% sodium azide) | |
ATF/UPA/URK/UROKINASE/u-PA | |
Rabbit | |
Affinity purification | |
RUO | |
5328 | |
Human | |
Liquid |
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