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PLN Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of PLN.

Manufacturer:  Abnova Corporation PAB13686

Catalog No. 89-116-801


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Description

Description

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq

Specifications

Specifications

PLN
Unconjugated
Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user.
PLN
CMD1P|PLB
Rabbit
IgG
100 ug
Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water to a concentration of 500μg/mL
Polyclonal
Identical to the related rat and mouse sequence.
Western Blot
Rabbit polyclonal antibody raised against synthetic peptide of PLN.
Lyophilized from 0.9mg NaCl, 0.2mg Na2HPO4 (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)
Lyophilized
PLN
A synthetic peptide corresponding to amino acids at N-terminus of human PLN.
Affinity purification
RUO
Primary
5350
Human, Murine, Rat
SDS
Documents
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