PLN Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of PLN.
Manufacturer: Abnova Corporation PAB13686
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq
|Western Blot (1 ug/mL) The optimal working dilution should be determined by the end user.|
|Store at -20°C on dry atmosphere. After reconstitution with 200μL of deionized water to a concentration of 500μg/mL|
|Identical to the related rat and mouse sequence.|
|Rabbit polyclonal antibody raised against synthetic peptide of PLN.|
|Lyophilized from 0.9mg NaCl, 0.2mg Na2HPO4 (5mg BSA, 0.05mg sodium azide, 0.05mg Thimerosal)|
|A synthetic peptide corresponding to amino acids at N-terminus of human PLN.|
|Human, Murine, Rat|
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