PML Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-117-237	100 μg

Catalog No. 89-117-237 Supplier Abnova Corporation Supplier No. PAB14682

Description

Rabbit polyclonal antibody raised against partial recombinant PML.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Specifications

• Antigen: PML
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against partial recombinant PML.
• Dilution: Western Blot (1:5000) Immunofluorescence (1:500) Immunohistochemistry (1:100) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from 10mM PBS, pH 7.4
• Gene: PML
• Gene Alias: MYL/PP8675/RNF71/TRIM19
• Gene Symbols: PML
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to the ring finger in the homodimerization region of human PML.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5371
• Test Specificity: This antibody recognizes normal PML proteins of lower molecular weight, and also recognizes the high molecular weight PML/RARalpha chimeric protein in promyelocytic leukemia patients.
• Target Species: Human
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with appropriate volume of deionized water to reach a final antibody concentration of 1mg/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized

For Research Use Only