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PML Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89126448 Shop All Abnova Corporation Products
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100 μL
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Catalog No. Quantity
89-126-448 100 μL
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Catalog No. 89-126-448 Supplier Abnova Corporation Supplier No. PAB24780
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Description

Rabbit polyclonal antibody raised against synthetic peptide of PML.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Specifications

Antigen PML
Applications Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of PML.
Dilution Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.2 (0.05% sodium azide)
Gene PML
Gene Alias MYL/PP8675/RNF71/TRIM19
Gene Symbols PML
Host Species Rabbit
Immunogen A synthetic peptide corresponding to PML.
Purification Method Antigen affinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5371
Test Specificity PML polyclonal antibody detects endogenous levels of PML protein.
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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