PML Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-131-373	400 μL

Catalog No. 89-131-373 Supplier Abnova Corporation Supplier No. PAB4343

Description

Rabbit polyclonal antibody raised against synthetic peptide of PML.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Sequence: PRKVIKMESEEGKEA

Specifications

• Antigen: PML
• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of PML.
• Dilution: ELISA (1:1000) Western Blot (1:100-500) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: PML
• Gene Alias: MYL/PP8675/RNF71/TRIM19
• Gene Symbols: PML
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to human PML.
• Purification Method: Protein G purification
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5371
• Test Specificity: This antibody recognize synthetic peptide (PRKVIKMESEEGKEA) containing a predicted sumoylation site of human PML.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only