PPM2C Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against recombinant PPM2C.

Manufacturer:  Abnova Corporation PAB21362

Catalog No. 89-122-853

Description

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq

Sequence: QDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAATHLIRHAVGNNEFGT

Specifications

• Antigen: PPM2C
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:20-1:50) Western Blot (1:250-1:500) The optimal working dilution should be determined by the end user.
• Gene: PPM2C
• Gene Alias: FLJ32517/MGC119646/PDH/PDP/PDP1/PDPC
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 uL
• Storage Requirements: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Description: Rabbit polyclonal antibody raised against recombinant PPM2C.
• Formulation: In PBS, pH 7.5 (40% glycerol, 0.02% sodium azide)
• Format: Liquid
• Gene Symbols: PPM2C
• Immunogen: Recombinant protein corresponding to amino acids of human PPM2C.
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 54704

For Research Use Only