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PPP1R1B (phospho T75), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of PPP1R1B.

Supplier:  Abnova Corporation PAB25435

Catalog No. 89-127-052


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Description

Description

Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM

Sequence: A-Y-Tp-P-P
Specifications

Specifications

PPP1R1B
Polyclonal
Rabbit polyclonal antibody raised against synthetic phosphopeptide of PPP1R1B.
In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
DARPP-32/DARPP32/FLJ20940
Rabbit
Affinity purification
RUO
84152
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Immunofluorescence
Unconjugated
Immunofluorescence (1:100-1:200) The optimal working dilution should be determined by the end user.
PPP1R1B
PPP1R1B
Synthetic phosphopeptide corresponding to residues surrounding T75 of human PPP1R1B.
100 μg
Primary
Human, Mouse, Rat
Liquid
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