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Description
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
Specifications
Specifications
| Antigen | PRKAA1 |
| Applications | ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic phosphopeptide of PRKAA1. |
| Dilution | Western Blot (0.1-1 ug/mL) ELISA (0.01-0.1 ug/mL) Immunoprecipitation (2-5 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | In TBS, pH 7.2 (BSA, 10% Proclin300) |
| Gene | PRKAA1 |
| Gene Alias | AMPK/AMPKa1/MGC33776/MGC57364 |
| Gene Symbols | PRKAA1 |
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