PRKAB1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of PRKAB1.
Manufacturer: Abnova Corporation PAB18144
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and noncatalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic peptide of PRKAB1.|
|In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|A synthetic peptide corresponding to human PRKAB1.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|This antibody is specific to PRKAB1.|
|ELISA, Immunohistochemistry (PFA fixed), Western Blot|
|Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:20000) The optimal working dilution should be determined by the end user.|
|Human, Murine, Rat|
For Research Use Only