PRKAR2B Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of PRKAR2B.

Supplier:  Abnova Corporation PAB4582

Catalog No. 89-131-480

Description

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq

Specifications

• Antigen: PRKAR2B
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of PRKAR2B.
• Formulation: In PBS (0.09% sodium azide)
• Gene Alias: PRKAR2/RII-BETA
• Host Species: Rabbit
• Purification Method: Protein G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 5577
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Dilution: ELISA (1:1000) Western Blot (1:100-500) The optimal working dilution should be determined by the end user.
• Gene: PRKAR2B
• Gene Symbols: PRKAR2B
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PRKAR2B.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Liquid

For Research Use Only