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PSEN1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.

Manufacturer:  Abnova Corporation PAB12993

Catalog No. 89-116-248


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Description

Description

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq

Specifications

Specifications

PSEN1
Unconjugated
Western Blot (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
PSEN1
AD3|FAD|PS1|S182
Rabbit
100 ug
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
This antibody has no cross-reactivity to presenilin2.
Immunohistochemistry (PFA fixed), Western Blot
Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.
In PBS (0.02% sodium azide)
Liquid
PSEN1
A synthetic peptide corresponding to C-terminus 23 amino acids of human PSEN1.
RUO
Primary
5663
Human, Murine, Rat
SDS
Documents
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