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PSEN1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.

Manufacturer:  Abnova Corporation PAB11738

Catalog No. 89-115-344

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq

Specifications

Specifications

PSEN1
Lot specific
Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.
In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Liquid
PSEN1
A synthetic peptide corresponding to N-terminus of human PSEN1.
100 uL
Store at 4°C.
Polyclonal
Human
Immunohistochemistry (PFA fixed)
Unconjugated
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:30) The optimal working dilution should be determined by the end user.
PSEN1
AD3|FAD|PS1|S182
Rabbit
Immunoaffinity purification
RUO
Primary
5663
SDS
Documents
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