PSEN1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-449	100 μL

Catalog No. 89-126-449 Supplier Abnova Corporation Supplier No. PAB24781

Description

Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq]

Specifications

• Antigen: PSEN1
• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.
• Dilution: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.2 (0.05% sodium azide)
• Gene: PSEN1
• Gene Alias: AD3/FAD/PS1/S182
• Gene Symbols: PSEN1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to PSEN1.
• Purification Method: Antigen affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5663
• Test Specificity: PSEN1 polyclonal antibody detects endogenous levels of PSEN1 protein.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only