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Description
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq]
Specifications
Specifications
| Antigen | PSENEN (KLH) |
| Applications | Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide conjugated to KLH. |
| Dilution | Western Blot (5-10 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | Lyophilized from purified antibody |
| Gene | PSENEN |
| Gene Alias | MDS033/MSTP064/PEN-2/PEN2 |
| Gene Symbols | PSENEN |
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For Research Use Only
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