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PTEN Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of PTEN.

Manufacturer:  Abnova Corporation PAB13149

Catalog No. 89-116-396


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Description

Description

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq

Specifications

Specifications

PTEN
Unconjugated
Western Blot (2 ug/mL) The optimal working dilution should be determined by the end user.
PTEN
10q23del|BZS|MGC11227|MHAM|MMAC1|PTEN1|TEP1
Rabbit
100 ug
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
Human, Murine
Western Blot
Rabbit polyclonal antibody raised against synthetic peptide of PTEN.
In PBS (0.02% sodium azide)
Liquid
PTEN
A synthetic peptide corresponding to N-terminus of human PTEN.
RUO
Primary
5728
SDS
Documents
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