PTEN Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of PTEN.
Manufacturer: Abnova Corporation PAB13149
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq
|Western Blot (2 ug/mL) The optimal working dilution should be determined by the end user.|
|Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Rabbit polyclonal antibody raised against synthetic peptide of PTEN.|
|In PBS (0.02% sodium azide)|
|A synthetic peptide corresponding to N-terminus of human PTEN.|
For Research Use Only