PTEN Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-131-280	400 μL

Catalog No. 89-131-280 Supplier Abnova Corporation Supplier No. PAB4118

Description

Rabbit polyclonal antibody raised against synthetic peptide of PTEN.

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq

Specifications

• Antigen: PTEN
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of PTEN.
• Dilution: ELISA (1:1000) Western Blot (1:100-500) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: PTEN
• Gene Alias: 10q23del/BZS/MGC11227/MHAM/MMAC1/PTEN1/TEP1
• Gene Symbols: PTEN
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PTEN.
• Purification Method: Protein G purification
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5728
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only