PTK2B (phospho Y402), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-999	100 μg

Catalog No. 89-126-999 Supplier Abnova Corporation Supplier No. PAB25352

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTK2B.

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq

Sequence: D-I-Yp-A-E

Specifications

• Antigen: PTK2B
• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTK2B.
• Dilution: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (without Mg²⁺ and Ca²⁺), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene: PTK2B
• Gene Alias: CADTK/CAKB/FADK2/FAK2/FRNK/PKB/PTK/PYK2/RAFTK
• Gene Symbols: PTK2B
• Host Species: Rabbit
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Y402 of human PTK2B.
• Purification Method: Affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2185
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only