PTPN11 (phospho Y580), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTPN11.

Supplier:  Abnova Corporation PAB25889

Catalog No. 89-127-520

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq

Sequence: R-V-Yp-E-N

Specifications

• Antigen: PTPN11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
• Gene: PTPN11
• Gene Symbols: PTPN11
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Y580 of human PTPN11.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed)
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTPN11.
• Formulation: In PBS (without Mg²⁺ and Ca²⁺), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Alias: BPTP3/CFC/MGC14433/NS1/PTP-1D/PTP2C/SH-PTP2/SH-PTP3/SHP2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5781
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only