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PTPN11 (phospho Y580), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTPN11.

Supplier:  Abnova Corporation PAB25889

Catalog No. 89-127-520


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Description

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq

Sequence: R-V-Yp-E-N
Specifications

Specifications

PTPN11
Polyclonal
Unconjugated
Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
PTPN11
PTPN11
Synthetic phosphopeptide corresponding to residues surrounding Y580 of human PTPN11.
100 μg
Primary
Human, Mouse, Rat
Liquid
Immunohistochemistry (PFA fixed)
1 mg/mL
Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTPN11.
In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
BPTP3/CFC/MGC14433/NS1/PTP-1D/PTP2C/SH-PTP2/SH-PTP3/SHP2
Rabbit
Affinity chromatography
RUO
5781
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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