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PYCARD Rabbit anti-Human, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89133746 Shop All Abnova Corporation Products
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100 μg
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Catalog No. Quantity
89-133-746 100 μg
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Catalog No. 89-133-746 Supplier Abnova Corporation Supplier No. PAB8553

Description

Rabbit polyclonal antibody raised against synthetic peptide of PYCARD.

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen PYCARD
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description PYD and CARD domain containing
Formulation In PBS, pH 7.2 (30% glycerol, 0.5mg/mL BSA, 0.01% thimerosal)
Gene PYCARD
Gene Alias ASC, CARD5, MGC10332, TMS, TMS-1, TMS1
Gene Symbols PYCARD
Host Species Rabbit
Immunogen A synthetic peptide corresponding to residues surrounding amino acids 185 of human PYCARD.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29108
Test Specificity The affinity purified antibody detects the 25kDa human and rat ASC/TMS1. HL60 cell lysate can be used as a positive control.
Target Species Human, Rat
Content And Storage Store at -20°C. For long term storage store at -80°C. Aliquot to avoid repeated freezing and thawing.
Form Liquid
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