PYGL Rabbit anti-Human, Monkey, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of PYGL.

Supplier:  Abnova Corporation PAB28175

Catalog No. 89-129-682

Description

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, or Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq

Specifications

• Antigen: PYGL
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of PYGL.
• Formulation: In PBS (0.09% sodium azide)
• Gene Alias: GSD6
• Host Species: Rabbit
• Purification Method: Immunoaffinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5836
• Target Species: Human, Monkey
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/ml)
• Gene: PYGL
• Gene Symbols: PYGL
• Immunogen: A synthetic peptide corresponding to 17 amino acids at C-terminus region of human PYGL.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Test Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only