RAF1 (phospho T269), Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human RAF1.
Supplier: Abnova Corporation PAB29218
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic phosphopeptide of human RAF1.
|In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
|Immunohistochemistry (PFA fixed)
|Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
|Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T269 of human RAF1.
|This antibody detects endogenous levels of RAF1 only when phosphorylated at threonine 269.
|Store at -20°C.
Avoid repeated freezing and thawing.
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For Research Use Only