RAF1 (phospho S471), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of RAF1.

Supplier:  Abnova Corporation PAB0593

Catalog No. 89-114-290

Description

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq

Specifications

• Antigen: RAF1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of RAF1.
• Formulation: In PBS (0.09% sodium azide)
• Gene Alias: CRAF/NS5/Raf-1/c-Raf
• Host Species: Rabbit
• Purification Method: Protein A purification
• Regulatory Status: RUO
• Gene ID (Entrez): 5894
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Dot Blot, ELISA
• Conjugate: Unconjugated
• Dilution: Dot Blot (1:100-500) The optimal working dilution should be determined by the end user.
• Gene: RAF1
• Gene Symbols: RAF1
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S471 of human RAF1.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

For Research Use Only