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MilliporeSigma™ Rabbit anti-Ribophorin I/RPN-I, Polyclonal,

Catalog No. ABS1587 Shop All MilliporeSigma Products
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ABS1587 100 μL
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Catalog No. ABS1587 Supplier MilliporeSigma™ Supplier No. ABS1587
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Description

Rabbit Polyclonal Antibody

Specifically detects Ribophorin I/RPN-I in Canine, Human, Rat samples, and it is validated for Western Blotting

Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 (EC 2.4.99.18; UniProt P04843; also known as Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67kDa subunit, Ribophorin I, RPN-I, Ribophorin-1) is encoded by the RPN1 gene (Gene ID 6184) in human. Ribophorin I is an ER transmembrane protein and a subunit of the mammalian Oligosaccharyltransferase (OST) complex. Ribophorin I binds newly synthesized target proteins and delivers them to the catalytic core of the OST complex. Association of ribophorin I with newly synthesized membrane proteins was observed after the exit of the nascent chain from the Sec61 translocon, and it was unaffected by the N-glycosylation status. Ribophorin I is reported to preferentially interact with misfolded over native ribonuclease A. In addition, Ribophorin I is shown to complex with another ER protein malectin and enhance malectin's ability to prevent the secretion of the folding-defective proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ribophorin I/RPN-I
Applications Western Blot
Classification Polyclonal
Formulation Rabbit polyclonal serum with 0.05% sodium azide.
Gene Accession No. P04843
Gene Symbols RPN1
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to the C-terminal sequence of human Ribophorin I/RPN-I.
Purification Method Unpurified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_002941
Target Species Canine, Human, Rat
Content And Storage Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Form Serum
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For Research Use Only

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