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Description
In mice, inactivation of the Rtel (regulator of telomere length) gene has been shown to cause chromosome breaks, fusions, and telomere loss. In addition, Rtel is required for telomere elongation. Therefore, the mouse Rtel gene regulates chromosome stability and telomere length. This gene is the human ortholog of the mouse Rtel gene, so its protein product may play similar roles in humans. It is located in a gene-rich cluster on chromosome 20, with other potential tumor-related genes, such as TNFRSF6B. Multiple transcript variants encoding different isoforms have been described for this gene, although the full-length nature of not all variants is known. [provided by RefSeq
Specifications
Specifications
| Antigen | RTEL1 |
| Applications | ELISA, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of RTEL1. |
| Dilution | The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide) |
| Gene | RTEL1 |
| Gene Alias | C20orf41/DKFZp434C013/KIAA1088/NHL/RTEL/bK3184A7.3 |
| Gene Symbols | RTEL1 |
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