MilliporeSigma™ Rabbit anti-S1P Lyase, Polyclonal,

Catalog No.	Quantity
ABS563MI	100 μg

Catalog No. ABS563MI Supplier MilliporeSigma™ Supplier No. ABS563

Description

Rabbit Polyclonal Antibody

Specifically detects S1P Lyase in Human samples, and it is validated for Immunohistochemistry, Western Blotting

Sphingosine-1-phosphate lyase 1 (EC 4.1.2.27; UniProt O95470; also known as hSPL, S1P lyase, Sphingosine-1-phosphate aldolase, SPL 1, SP-lyase 1) is a type III single-pass ER membrane protein encoded by the SGPL1 (Also known as S1PL, SPL) gene in human (Gene ID 8879). SP-lyase 1 catalyzes the irreversible retro-aldol cleavage of sphingosine 1-phosphate to 2-hexadecenal and phosphoethanolamine. S1P lyase activity knockout is reported to offer protection in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), by preventing T cell egress from the lymph nodes into central nervous system (CNS). S1P lyase overexpression is also demonstrated to potentiate serum withdrawal-induced apoptosis in HEK293 cultures.

Specifications

• Antigen: S1P Lyase
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: O95470
• Gene Symbols: SGPL1; KIAA1252
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human S1P Lyase.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_003892
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only