SENP6 Rabbit anti-Human, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of SENP6.
Manufacturer: Abnova Corporation PAB1849
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM
|Western Blot (1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.|
|Protein G purification|
|ELISA, Immunohistochemistry, Western Blot|
|Rabbit polyclonal antibody raised against synthetic peptide of SENP6.|
|In PBS (0.09% sodium azide)|
|A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SENP6.|
|Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
For Research Use Only