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Description
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Specifications
Specifications
| Antigen | SH3BP2 |
| Applications | ELISA, Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic phosphopeptide of SH3BP2. |
| Dilution | ELISA (1:2000-1:10000) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user. |
| Formulation | In 20mM KH2PO4, 150mM NaCl, pH 7.2 (0.01% sodium azide) |
| Gene | SH3BP2 |
| Gene Alias | 3BP2/CRBM/CRPM/FLJ42079/RES4-23 |
| Gene Symbols | SH3BP2 |
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