SHANK3, Rabbit, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-127-107	100 μg

Catalog No. 89-127-107 Supplier Abnova Corporation Supplier No. PAB25490

Description

Rabbit polyclonal antibody raised against synthetic peptide of SHANK3.

This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD) which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene are a major causitive factor in the neurological symptoms of 22q13.3 deletion syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq

Specifications

• Antigen: SHANK3
• Applications: ELISA, Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of SHANK3.
• Dilution: Western Blot (1 ug/mL) Immunohistochemistry (2.5 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.02% sodium azide)
• Gene: SHANK3
• Gene Alias: DEL22q13.3/KIAA1650/PROSAP2/PSAP2/SPANK-2
• Gene Symbols: SHANK3
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to internal region of human SHANK3.
• Purification Method: Affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 85358
• Test Specificity: At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only