SMC1A Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic peptide of SMC1A.
Manufacturer: Abnova Corporation PAB26744
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeqSequence: G-S-Sp-Q-G
|Rabbit polyclonal antibody raised against synthetic peptide of SMC1A.|
|In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|A synthetic peptide corresponding to residues surrounding S957 of human SMC1A.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Immunohistochemistry (PFA fixed), Western Blot|
|Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.|
For Research Use Only