MilliporeSigma™ Rabbit anti-SPPL2a, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABF112

Catalog No. ABF112MI

Description

Specifically detects SPPL2a in Human samples, and it is validated for Flow Cytometry, Western Blotting

Signal-peptide-peptidase-like 2A (SPPL2a), a member of aspartic protease family, is an ubiquitously expressed intramembrane protease that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. It has been implicated in the proteolysis of TNF-a, Fas Ligand, and Bri2. SPPL2a exhibits about 7-0% homology with SPPL2b, however, the later is expressed primarily in adrenal cortex and mammary gland. Over-expressed SPPL2a is observed in late endosomal compartments where it co-localizes with Rab7. Its lysosomal/late endosomal sorting is dependent on a single tyrosine-based motif (Tyr498) in its cytoplasmic tail.

Specifications

• Antigen: SPPL2a
• Classification: Polyclonal
• Gene Accession No.: Q8TCT8
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human

• Applications: Flow Cytometry, Western Blot
• Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: SPPL2A; IMP3; PSL2; PSEC0147
• Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human SPPL2a.
• Quantity: 100 μg
• Research Discipline: Inflammation and Immunology
• Gene ID (Entrez): NP_116191
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only