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Description
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NFkb in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq
Specifications
Specifications
| Antigen | SQSTM1 |
| Applications | ELISA, Immunofluorescence, Immunohistochemistry, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of SQSTM1. |
| Dilution | Western Blot (1:1000) Immunohistochemistry (1:50-100) Immunofluorescence (1:50-100) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.09% sodium azide) |
| Gene | SQSTM1 |
| Gene Alias | A170/OSIL/PDB3/ZIP3/p60/p62/p62B |
| Gene Symbols | SQSTM1 |
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