MilliporeSigma™ Rabbit anti-SR-alpha, Polyclonal,

Catalog No.	Quantity
ABS1591	100 μL

Catalog No. ABS1591 Supplier MilliporeSigma™ Supplier No. ABS1591

Description

Rabbit Polyclonal Antibody

Specifically detects SR-alpha in Canine, Human, Rat samples, and it is validated for Immunoprecipitation, Western Blotting

Signal recognition particle receptor subunit alpha (UniProt P08240; also known as Docking protein alpha, DP-alpha, SR-alpha, SRalpha) is encoded by the SRPR gene (Gene ID 6734) in human. Secretory proteins typically possess N-terminal hydrophobic signal sequences that direct them to the endoplasmic reticulum (ER) membrane, where they are translocated into the ER lumen for subsequent vesicular transport. Signal recognition particle (SRP) delivers target nascent secretory proteins, while they are still being synthesized, together with the associated ribosome to the ER protein translocon (Sec61 complex) via the interaction with SRP receptor (SR) on the ER membrane. SR is a heterodimer composed of a 70kDa peripheral membrane protein (SR alpha subunit or SRα) and a 30kDa singlel-trans membrane protein (SR beta subunit or SRβ). SRα contains an N-terminal SRX domain that mediates its association with SRβ and a C-terminal region which has high homology to the NG domain of SRP54, including a functional GTPase domain. SRβ also possesses a GTPase domain, which interacts with SRα SRX domain only when SRα is in the GTP bound state. SRα forms the major interaction interface with SRP.

Specifications

• Antigen: SR-alpha
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Accession No.: P08240
• Gene Symbols: SRPR
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human SR-alpha.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_003130
• Target Species: Canine, Human, Rat
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Form: Serum

For Research Use Only